Tolerance to skin and vascularized cardiac allografts using mixed chimerism.
نویسندگان
چکیده
I N recent years a number of methods have been developed to induce donor-specific transplantation tolerance in adult recipients using bone marrow transplantation. 1-4 One approach. using a mixture of syngeneic and allogeneic bone marrow to prepare allogeneic chimeras (A + B A) has been demonstrated to be effective in achieving longterm donor-specific transplantation tolerance to alloantigens in mice. 5 We adapted the model of mixed chimerism
منابع مشابه
Induction of donor-specific transplantation tolerance to skin and cardiac allografts using mixed chimerism in (A + B-->A) in rats.
Mixed allogeneic chimerism (A + B-->A) was induced in rats by reconstitution of lethally irradiated LEW recipients with a mixture of T-cell depleted (TCD) syngeneic and TCD allogeneic ACI bone marrow. Thirty-seven percent of animals repopulated as stable mixed lymphopoietic chimeras, while the remainder had no detectable allogeneic chimerism. When evaluated for evidence of donor-specific transp...
متن کاملDifferent mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Regulatory T cells (Treg) are important in peripheral tolerance, but their role in establishing and maintaining hematopoietic mixed chimerism and generating central tolerance is unclear. We now show that costimulation blockade using a donor-specific transfusion and anti-CD154 antibody applied to mice given bone marrow and simultaneously transplanted with skin allografts leads to hematopoietic c...
متن کاملA clinically relevant CTLA4-Ig-based regimen induces chimerism and tolerance to heart grafts.
BACKGROUND We determined whether a nontoxic CTLA4-Ig-based conditioning regimen effected mixed chimerism and donor-specific tolerance when heart and bone marrow were transplanted simultaneously. METHODS Fully mismatched rat strain combinations were used. Recipients received total-body irradiation (300 centigrays), bone marrow (10(8) cells), and cardiac transplants from the donor on day 0. Sub...
متن کاملMixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine.
BACKGROUND Tolerance to cardiac allografts has not been achieved in large animals using methods that are readily applicable to human recipients. We investigated the effects of mixed hematopoietic chimerism on cardiac allograft survival and chronic rejection in miniature swine METHODS Recipients were T-cell depleted using a porcine CD3 immunotoxin, and each received either of two nonmyeloablat...
متن کاملDonor-Specific Regulatory T Cells Acquired from Tolerant Mice Bearing Cardiac Allograft Promote Mixed Chimerism and Prolong Intestinal Allograft Survival
The induction of donor-specific transplant tolerance has always been a central problem for small bowel transplantation (SBT), which is thought to be the best therapy for end-stage bowel failure. With the development of new tolerance-inducing strategies, mixed chimerism induced by co-stimulation blockade has become most potent for tolerance of allografts, such as skin, kidney, and heart. However...
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 24 6 شماره
صفحات -
تاریخ انتشار 1992